Neuroimaging Study of Factors Related to Exercise

Completed · Not applicable

Conditions studied: Obesity

In brief

This study aims to support the hypothesis that brain processes underlying reward processing and impulse control contribute to obesity and to adherence in a new exercise regimen.

Key facts

Study ID

NCT02010463

Run by

University of Kansas Medical Center

People needed

200

Starts

2011-10-01

Expected to finish

2020-01-15

Last updated by the study team

2020-03-25

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI >25 to < 40±1
• Must live in the Greater Kansas City area for at least 1 year
• Willing to exercise
• Provide written approval from a licensed physician that they are healthy enough to participate in a program of moderate physical activity and maximum O2 testing
• All participants must be sedentary except for casual recreation such as softball, bowling, etc.

You may not qualify if…

• Color-blindness
• Left-handedness
• Any diagnosed neurological disorder or conditions that preclude MRI scanning (e.g., metal in body)
• Participation in a research project involving weight loss or physical activity in the previous 6 months
• Subjects who smoke
• Subjects use medications that affect metabolism (i.e. thyroid, beta blockers), use medications that affect appetite (i.e. Meridia) or cannot exercise (i.e. walk)
• Participants will be excluded by study personnel following interview if they exhibit eating disorders, binge eating, depression or drug addiction
• Metabolic disease that would affect energy balance (e.g. diabetes mellitus or hypothyroidism)
• Pregnant during the previous 6 months, are lactating, or plan pregnancy within 12 months
• Individuals who are not weight stable (± 4.5kg) within the previous year.
• Serious medical risks such as type 1-diabetes, cancer, recent cardiac event (i.e. heart attack, angioplasty, etc.)
• High blood pressure
• Current use of smoking/tobacco products or initiation of the use of smoking/tobacco products during the study and alcohol abuse and any history of dependence
• Subject IQ is less that 80
• Reported radiation exposure from CT, PET, fluoroscopic or nuclear medicine studies within the previous year, or other radiation exposure at the discretion of the PI

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kansas — Lawrence, Kansas, United States

Full record on ClinicalTrials.gov

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