Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria

Completed · Phase 2 · Has a placebo group

Conditions studied: Type 2 Diabetes Mellitus With Diabetic Nephropathy

In brief

NADPH oxidase enzymes (NOX) have been implicated in the development of several diabetic complications including diabetic nephropathy. GKT137831 is the first in class NOX1/4 inhibitor. The primary objective of this study is to evaluate the efficacy of oral GKT137831 in patients with residual albuminuria despite maximal inhibition of the renin angiotensin aldosterone system.

Key facts

Study ID
NCT02010242
Run by
Calliditas Therapeutics AB
People needed
136
Starts
2013-10-01
Expected to finish
2015-03-01
Last updated by the study team
2025-02-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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