Assessment of Coronary Artery Calcium in Active Duty Enlisted Military Members With 10 or More Years of Service

Stopped early

Conditions studied: Atherosclerosis, Plaque, Atherosclerotic

In brief

Hypothesis: Enlisted military members with 10 or more years of service and at least one cardiovascular risk factor will demonstrate a higher risk of future cardiac events as assessed by coronary artery calcium (CAC) scoring than the risk calculated by the Framingham Risk Score.

Key facts

Study ID

NCT02009930

Run by

David Grant U.S. Air Force Medical Center

People needed

112

Starts

2013-11-05

Expected to finish

2018-07-18

Last updated by the study team

2020-06-09

Who can join

Age: 35 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Active Duty Military Members with at least 10 years of service
• Enlisted Rank
• Males 35 years and older OR Females 45 years and older (please note the age difference is due to the fact that female plaque formation with calcification has been shown to lag that of males by about 10 years)
• One or More of the Following Risk Factors:
• Smoker - at least 5 pack years in the past 5 years (pack year = number of packs per day number of years of smoking)
• Diabetic (Fasting glucose of >125 mg/dL on two or more blood draws, or Random Blood Glucose of >200 mg/dL on a single blood draw, or Hemoglobin A1C >6.5%, or previous diagnosis of diabetes listed in the subject's medical record) or Pre-diabetic (Fasting glucose >100 on two or more blood draws or Hgb A1C 5.7-6.4)
• Hypertension (Systolic BP > 140 or Diastolic BP >90 or on blood pressure medications or diagnosis of hypertension in medical record)
• Waist Circumference > 40 inches for males or >35 inches for females
• Hyperlipidemia (LDL>130, HDL<40 for males, HDL <50 for females, Triglycerides >200, on lipid lowering medications and/or diagnosis of hyperlipidemia in medical record)

You may not qualify if…

• Males <35 years old
• Women <45 years old (please note the age difference is due to the fact that female plaque formation with calcification has been shown to lag that of males by about 10 years)
• Officer Rank - officers are excluded as we are looking at the enlisted culture in the military.
• History of any of the following:
• Coronary Artery Disease (CAD)
• Coronary Artery Bypass Grafting (CABG)
• Myocardial Infarction (MI)
• Percutaneous Intervention/Stent Placement (PCI)
• Angina
• Radiotherapy (external beam, brachytherapy, radiopharmaceutical)
• Under the care of any of the following types of providers in the past 12 months (As these subjects are at greater risk of having had significant radiation exposure to the chest over the past 12 months):
• Radiation/Medical Oncologist
• Interventional Radiologist
• Cardiologist
• Cardiothoracic Surgeon
• Vascular Surgeon
• Females who think they may be pregnant
• Pregnant females

Where it is running

• David Grant USAF Medical Center — Travis Air Force Base, California, United States

Full record on ClinicalTrials.gov

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