Esophageal String Test in Eosinophilic Esophagitis

Running, not enrolling

Conditions studied: Eosinophilic Esophagitis

In brief

The overall goal of this study is to develop a novel minimally invasive device, the Esophageal String Test (EST) to monitor esophageal inflammation during treatment of the rare disease Eosinophilic Esophagitis (EoE) in a safe and efficacious manner. This study is broken down into 2 specific aims: Specific Aim 1: Identify the EoE Biomarker Panel (EBP) that will improve the sensitivity and specificity of the EST for documenting esophageal inflammation in a 1-hour time point. Specific Aim 2: Validate the ability of the EST EBP to monitor therapeutic efficacy in a 1-hour sampling time. Funding Source - FDA OOPD

Key facts

Study ID

NCT02008903

Run by

University of Colorado, Denver

People needed

440

Starts

2009-01-01

Expected to finish

2027-01-01

Last updated by the study team

2026-05-15

Who can join

Age: 7 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients undergoing esophagogastroduodenoscopy (EGD) at Children's Hospital Colorado, or
• Patients from a participating site in whom an inflammatory GI disease is suspected.
• Patients with symptoms of:
• abdominal pain,
• vomiting,
• growth delay, or
• malabsorption for which an etiology has not been determined.
• Patients with chronic eosinophilic esophagitis (EoE) in whom symptoms suggest ongoing inflammation.

You may not qualify if…

• Patients suffering from bleeding diathesis, or any other comorbid condition which their doctor feels may put them at additional risk.
• Patients with a family history of connective tissue disease.
• Patients undergoing a therapeutic endoscopy (such as dilatation, sclerotherapy, variceal banding).
• Patients with a history of:
• esophageal stricture, or
• surgery such as fundoplication, or
• allergy to gelatin, or
• inability to swallow pills.

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• Northwestern University — Chicago, Illinois, United States
• Lurie Children's Hospital — Chicago, Illinois, United States
• OSF St Francis Medical Center — Peoria, Illinois, United States
• Indiana University — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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