MR Imaging of Perinatal Brain Injury

Completed

Conditions studied: Perinatal White Matter Brain Injury

In brief

The purpose of this study is to collect and compare information from cranial ultrasounds, magnetic resonance imaging scans, neurological exam and neuropsychological assessments of children. The investigators hope that the information collected in this study will help with early screening, diagnosis and treatment of brain injury in newborns as well as identify a connection between MR imaging (MRI-magnetic resonance imaging, MRS-magnetic resonance spectroscopy) and neurodevelopmental outcome.

Key facts

Study ID

NCT02008045

Run by

University of Pittsburgh

People needed

557

Starts

2009-07-01

Expected to finish

2025-06-02

Last updated by the study team

2026-01-13

Who can join

Age: 0 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Preterm babies and neonates with congenital heart disease
• Term Neonates

You may not qualify if…

• Severe congenital brain malformation
• Significant chromosomal abnormality / syndrome which could confound the neurodevelopmental follow up data
• Preterm birth and congenital heart disease
• Focal neurological abnormality
• Chronic seizures
• Severe congenital brain malformation
• Significant chromosomal abnormality/ syndrome which could confound the neurodevelopmental follow up data
• Major pregnancy complication (diabetes, eclampsia)
• Sepsis
• ECMO
• Significant birth trauma and/or hypoxic ischemic injury

Where it is running

• Children's Hospital of Pittsburgh of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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