Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis

Completed · Not applicable

Conditions studied: Diabetic Ketoacidosis

In brief

To determine if co-administration of subcutaneous (SQ)Insulin glargine in combination with intravenous (IV) insulin decreases the time to resolution of ketoacidosis and requirement for ICU admission compared to IV insulin with delayed administration of SQ glargine for the treatment of diabetic ketoacidosis (DKA).

Key facts

Study ID

NCT02006342

Run by

The University of Texas Health Science Center, Houston

People needed

40

Starts

2012-11-01

Expected to finish

2013-04-01

Last updated by the study team

2017-05-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >18 years
• Blood Glucose >200
• potential of hydrogen (pH) < 7.3
• Bicarbonate < 18
• Ketonemia or Ketonuria
• Anion Gap > or = 16

You may not qualify if…

• Age < 18 years
• Pregnant
• End state renal disease (ESRD)
• Prisoners
• Patients in shock or requiring emergency surgery
• Those unwilling to consent for the trial
• Allergic to Insulin Glargine

Where it is running

• Lyndon B Johnson Hospital — Houston, Texas, United States
• Memorial Herman Hospital-Texas Medical Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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