Cognitive Effects of Anesthesia on Children

Completed

Conditions studied: Procedures Requiring Anesthesia

In brief

Anesthesia for more than 120 minutes given to children less than 2 years of age without coexisting diseases of the central nervous system or the heart cause long-term impairment of recognition memory.

Key facts

Study ID

NCT02005185

Run by

University of California, San Francisco

People needed

162

Starts

2013-11-01

Expected to finish

2018-11-15

Last updated by the study team

2020-09-11

Who can join

Age: 6 and older, up to 11. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• General anesthesia for more than 120 minutes between birth and 2 years of age or between ages 4-7
• General anesthesia for less than 30 minutes before the age of 2.
• Use of volatile anesthetic (sevoflurane, isoflurane, halothane or desflurane) with or without nitrous oxide for maintenance of anesthesia.
• Use of fentanyl or morphine as opioids and midazolam as premedication is acceptable. Propofol used for induction only is acceptable.
• Control subjects must never have been exposed to anesthesia or sedation for any procedure.
• English and Spanish speaking subjects

You may not qualify if…

• Use of any other agents such as ketamine, meperidine, barbiturates, etomidate, methoxyflurane, chloral hydrate, methadone or lorazepam.
• Low birth weight (<25th percentile)
• premature birth at <36 weeks
• color blindness
• history of brain disease including head trauma
• presence of congenital heart disease
• any other metabolic disease (i.e. diabetes),cancer, or known genetic syndrome.
• significant low blood pressure during their surgery (<30% of baseline for >5min)
• abnormal temperature (deviation from 36.5 degrees C by >1.5 degree C at any point)
• slow heart rate
• low blood oxygen saturation (<93% for >5min.)
• high arterial carbon dioxide levels (>60mm Hg for >5min.)
• control subjects are excluded for any exposure to anesthesia or sedation

Where it is running

• University of California, Davis Center for Mind and Brain — Davis, California, United States
• UCSF Benioff Children's Hospital Oakland — Oakland, California, United States
• UCSF — San Francisco, California, United States

Full record on ClinicalTrials.gov

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