Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery

Completed · Phase 4 · Has a placebo group

Conditions studied: Heart Disease

In brief

Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery

Key facts

Study ID

NCT02004613

Run by

The Cleveland Clinic

People needed

798

Starts

2013-06-01

Expected to finish

2020-12-18

Last updated by the study team

2021-04-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-85 years old;
• Scheduled for cardiac surgery with bypass (CABG, valve, or combined);
• Able to provide a written informed consent;
• Hemodynamically stable (heart rate>= 55).

You may not qualify if…

• Sick sinus syndrome or Wolff-Parkinson-White syndrome
• Atrio-ventricular block
• Hypersensitivity or known allergy to dexmedetomidine
• Hepatic disease, e.g. twice the normal level of liver enzymes
• Atrial fibrillation within 1 preoperative month;
• Permanent pacemaker;
• Use of amiodarone or dexmedetomidine within the last 30 days;
• Patients with an ejection fraction under 30% or who had severe heart failure
• Myocardial infarction in the previ¬ous 7 days;
• Body mass index =< 40 (BMI= mass (kg) / height (m)2);
• Those taking clonidine within last 48 hours.

Where it is running

• Cleveland Clinic Main — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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