Protein Intake & Insulin Action

Completed · Not applicable

Conditions studied: Obesity

In brief

The purpose of this proposal is to determine whether dietary protein restriction has beneficial effects on skeletal muscle insulin sensitivity and β-cell function in obese men and women.

Key facts

Study ID

NCT02004002

Run by

Washington University School of Medicine

People needed

15

Starts

2013-12-01

Expected to finish

2016-09-01

Last updated by the study team

2016-10-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index (BMI) between 30 and 50 kg/m2
• Subjects who are sedentary (<1.5 h of exercise/week)
• Subjects with a high habitual protein intake (>1.2 g/kg body mass/day)

You may not qualify if…

• Subjects with evidence of significant organ system dysfunction (e.g. diabetes, severe cardiovascular disease, hyperlipidemia, cirrhosis, hypogonadism, uncontrolled hypo- or hyperthyroidism; uncontrolled hypertension)
• Subjects with metal implants
• Individuals with cancer or cancer that has been in remission for <5 years,
• Individuals with dementia,
• Individuals who use tobacco products,
• Subjects who are taking medications known to affect glucose metabolism (e.g., steroids),
• Subjects taking medications to control certain medical conditions (e.g., hypertension) will be included if the drug regimen has been stable for at least 6 months before entering the study and is not expected to change during the study.
• Women who are pregnant due to changes in body composition and decreases in insulin sensitivity caused by pregnancy

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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