Assessment Of Vascular Health After Niacin Therapy (AVANT)
Completed · Not applicable · Has a placebo group
Conditions studied: Coronary Artery Disease, Carotid Artery Disease, Peripheral Artery Disease
In brief
This study is looking to see if niacin will lessen atherosclerotic plaque inflammation and favorably affect circulating levels of endothelial progenitor cells and microparticles in people with atherosclerotic disease on chronic statin therapy.
Key facts
- Study ID
- NCT02003638
- Run by
- University of Pennsylvania
- People needed
- 9
- Starts
- 2012-03-01
- Expected to finish
- 2013-01-01
- Last updated by the study team
- 2014-06-25
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men age 55 years and above with coronary artery disease or women age 65 years and above with coronary artery disease OR Men age 45 years and above with both coronary artery disease and carotid or lower extremity peripheral artery disease or women age 55 years and above with both coronary artery disease and carotid or lower extremity peripheral artery disease.
- Subjects must be on statin monotherapy, defined as a stable statin dose for at least 12 weeks, with no anticipated need for further titration during the study period
You may not qualify if…
- Anxiety or claustrophobia prohibiting imaging
- History of allergy to intravenous contrast, iodine, or shellfish
- Renal insufficiency
- History of allergy or severe intolerance to niacin
- History of diabetes mellitus or elevated fasting glucose
- Moderate to severe gout
- Peptic ulcer disease
- Acute coronary syndrome, transient ischemic attack or cerebrovascular accident, or acute limb ischemia in the preceding 12 months
- Heart failure or unstable angina pectoris
- Use of daily non-statin lipid-altering therapy prior to the initiation of study medication
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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