A Study of Oprozomib, Pomalidomide, and Dexamethasone in Adults With Primary Refractory or Relapsed and Refractory Multiple Myeloma
Stopped early · Phase 1
Conditions studied: Multiple Myeloma
In brief
The purpose of the Phase 1 part of the study is to determine the maximum tolerated dose and assess the safety, tolerability and activity of oprozomib in combination with pomalidomide and dexamethasone in adults with primary refractory or relapsed and refractory multiple myeloma. The purpose of the Phase 3 part of the study is to compare the efficacy for adults with primary refractory or relapsed and refractory multiple myeloma who are randomized to either oprozomib or placebo in combination with pomalidomide and dexamethasone.
Key facts
- Study ID
- NCT01999335
- Run by
- Amgen
- People needed
- 33
- Starts
- 2014-07-30
- Expected to finish
- 2019-04-25
- Last updated by the study team
- 2021-04-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- California Cancer Associates For Research and Exellence, cCare — Encinitas, California, United States
- James R. Berenson, MD, Inc. — West Hollywood, California, United States
- Innovative Clinical Research Institute — Whittier, California, United States
- Rocky Mountain Cancer Centers — Denver, Colorado, United States
- Oncology Hematology West PC, dba Nebraska Cancer Specialists — Omaha, Nebraska, United States
- Weill Cornell Medical College-New York Presbyterian Hospital — New York, New York, United States
- Levine Cancer Institute — Charlotte, North Carolina, United States
- Duke University Medical Center — Durham, North Carolina, United States
- Willamette Valley Cancer Institute and Research Center — Springfield, Oregon, United States
- Abramson Cancer Center of the University of Pennsylvania at Perelman Center for Advanced Medicine — Philadelphia, Pennsylvania, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Tennessee Oncology, PLLC / Sarah Cannon Research Institute — Nashville, Tennessee, United States
- The University of Texas M.D. Anderson Cancer Center — Houston, Texas, United States
- Cancer Care Centers of South Texas-HOAST — San Antonio, Texas, United States
- Virginia Cancer Specialists, PC — Fairfax, Virginia, United States
- Virginia Oncology Associates — Norfolk, Virginia, United States
- Yakima Valley Memorial Hospital/North Star Lodge — Yakima, Washington, United States
Full record on ClinicalTrials.gov
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