Stroke Feasibility Study

Completed · Phase 1/Phase 2

Conditions studied: Atrial Fibrillation, AFib

In brief

This is a feasibility study to assess the safety and efficacy of the AtriCure AtriClip when placed via Minimally Invasive Surgical Deployment to the Left Atrial Appendage. The purpose is for evaluation of Stroke Prevention in Patients with Non-Valvular Atrial Fibrillation who are unable to take Oral Anticoagulants.

Key facts

Study ID

NCT01997905

Run by

AtriCure, Inc.

People needed

13

Starts

2014-01-01

Expected to finish

2015-08-01

Last updated by the study team

2016-12-14

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is ≥ 18 years and ≤ 80 years of age.
• Patient has electrocardiographically confirmed non-valvular atrial fibrillation (paroxysmal, persistent, or longstanding persistent AF).
• CHADS2 or CHA2DS2VASc score ≥2.
• Patient has medical contraindication to long term anticoagulant therapy (OAC), defined as one or more of the following:
• history of intracranial bleeding (e.g. due to amyloid angiopathy or other condition) which renders patient unsafe for OAC;
• history of gastrointestinal, genitourinary, or respiratory tract bleeding due to permanent condition which renders patient unsafe for OAC;
• HAS-BLED Score ≥ 3.
• Patient is considered an acceptable surgical candidate, including use of general anesthesia.
• Female patients must be of non-child bearing potential, or have a negative pregnancy test within 7 days prior to index procedure.

You may not qualify if…

• Stroke within 30 days, or TIA within 3 days, respectively, prior to index procedure.
• Documented medical history of any penetrating trauma to thorax, or blunt trauma to thorax which resulted in a left pneumothorax or left hemothorax.
• Myocardial infarction within 60 days prior to index procedure.
• NYHA Class IV heart failure.
• Ejection fraction < 40% (based on baseline transthoracic echocardiography (TTE)).
• Prior attempted obliteration of left atrial appendage (percutaneous or open cardiac surgery).
• Previous catheter ablation with perforation or complication.
• Prior open cardiac surgery, or percutaneous coronary intervention with associated unintended cardiac perforation, or pericardial adhesions are suspected.
• History of pericarditis or pericardiocentesis.
• Active infection, septicemia, or fever of unknown origin.
• Concomitant elective surgical procedure (in addition to AtriClip placement) at the time of index procedure.
• Planned atrial arrhythmia ablation procedure within six months following index procedure.
• Underlying structural heart disease requiring planned surgical treatment within six months following the index procedure.
• Cardiac or thoracic surgical procedure within the thirty days prior to index procedure.
• Anticoagulation therapy for other medical condition (i.e. deep vein thrombosis) is required.
• Patient unable to discontinue thienopyridines (e.g. clopidogrel) or non-ASA antiplatelet agents 4 days pre-operatively and abstain for at least 2 days post-operatively.
• Renal Failure as defined by creatinine > 2.0 mg/dl (> 152.5 umol/L) and/or need for dialysis.
• Known carotid artery diameter stenosis greater than 80%.
• Patient has symptomatic or high-grade carotid disease (>70% bilaterally).
• Patient unable or unwilling to undergo transesophageal echocardiography (TEE).
• Presence of thrombus in the left atrium or LAA, as determined by baseline TTE or Computed Tomography Angiogram (CTA).
• Documented history of thrombophilic disorder, with diagnosis established via previous objective testing (e.g. familial screening for thrombophilia).
• Moderate to Severe Chronic Obstructive Pulmonary Disease (FEV1 or VC<70% predicted) or intolerant of single lung ventilation.
• History of Hypercoagulopathy
• Body Mass Index (BMI) > 35.

Where it is running

• St. Helena Hospital — St. Helena, California, United States
• Mercy Hospital — Miami, Florida, United States
• Franciscan St. Francis Health — Indianapolis, Indiana, United States
• Good Samaritan Hospital — Cincinnati, Ohio, United States
• Houston Methodist Hospital — Houston, Texas, United States
• University of Virginia — Charlottesville, Virginia, United States
• Aspirus — Wausau, Wisconsin, United States

Full record on ClinicalTrials.gov

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