Safety and Efficacy of Eculizumab in Refractory Generalized Myasthenia Gravis (REGAIN Study)

Completed · Phase 3 · Has a placebo group

Conditions studied: Refractory Generalized Myasthenia Gravis

In brief

The purpose of this study is to determine if eculizumab is safe and effective for the treatment of refractory generalized Myasthenia Gravis.

Key facts

Study ID

NCT01997229

Run by

Alexion Pharmaceuticals, Inc.

People needed

125

Starts

2013-12-01

Expected to finish

2016-06-01

Last updated by the study team

2019-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of California San Francisco-Fresno — Fresno, California, United States
• University of Southern California — Los Angeles, California, United States
• University of California-Irvine — Orange, California, United States
• University of California Davis Health System — Sacramento, California, United States
• California Pacific Medical Center — San Francisco, California, United States
• Stanford University School of Medicine — Stanford, California, United States
• Yale New Haven Hospital — New Haven, Connecticut, United States
• University of Florida Health Science Center — Jacksonville, Florida, United States
• University of Miami School of Medicine — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Georgia Regents University — Augusta, Georgia, United States
• Medical Associates of North Georgia — Canton, Georgia, United States
• Southern Illinois University School of Medicine — Springfield, Illinois, United States
• Indiana University — Indianapolis, Indiana, United States
• University of Iowa College of Medicine — Iowa City, Iowa, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Maryland Medical Center — Baltimore, Maryland, United States
• Johns Hopkins University School Of Medicine — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Lahey Clinic Inc. — Burlington, Massachusetts, United States
• Wayne State University School of Medicine — Detroit, Michigan, United States
• Las Vegas Clinic — Las Vegas, Nevada, United States
• Buffalo General Hospital — Buffalo, New York, United States
• University of Alabama — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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