Brain Connectivity in Age-Related Macular Degeneration

Completed

Conditions studied: Age-Related Macular Degeneration

In brief

This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function. The study team will assess whether the "brain signatures" associated with specific cognitive deficits differ in older adults with and without AMD.

Key facts

Study ID

NCT01996215

Run by

Duke University

People needed

238

Starts

2014-04-01

Expected to finish

2018-06-01

Last updated by the study team

2019-02-07

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• AMD
• Vision loss attributable to AMD
• Controls
• Age match (± 5 yrs)
• Gender match
• Education match (± 4yrs)
• Normal macular exam

You may not qualify if…

• AMD
• Other significant eye pathology
• Mod/severe dementia
• Communication barrier that precludes testing
• Controls
• Other significant eye pathology
• Mod/severe dementia
• Communication barrier that precludes testing
• MRI subset
• Devices or material incompatible with 3.0 Tesla MRI
• Conditions that may interfere with interpretation of fMRI (e.g. history of stroke, brain tumor or previous brain surgery; psychoactive medications; seizure disorder)
• Claustrophobia
• Left-handed
• Body weight > 300 lbs
• Pregnant women

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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