Bleach Bath Treatment of Adults With Atopic Dermatitis

Completed · Not applicable

Conditions studied: Atopic Dermatitis

In brief

This is pilot, mechanistic study to address whether bleach baths given to adult subjects with atopic dermatitis or eczema, who are colonized with the bacteria Staphylococcus aureus, will significantly alter their skin microbiome and in so doing improve their skin barrier, diminish expression of inflammatory proteins in the skin and improve itch. To answer these questions the investigators will perform a 3-month, pilot, investigator-initiated, single-center, open-label clinical study. This study will allow us to test the following hypothesis: 1) that bleach baths will normalize skin barrier function, 2) that bleach baths will diminish the local inflammatory response in the skin, and 3) that bleach baths will improve validated measures of itch (also called pruritus).

Key facts

Study ID

NCT01996150

Run by

University of Rochester

People needed

58

Starts

2014-01-01

Expected to finish

2017-06-01

Last updated by the study team

2018-01-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Moderate to severe Atopic dermatitis: Eczema Area and Severity Index (EASI) score ≥ 10.
• Skin culture positive for Staphylococcus aureus
• Must have active skin disease on the day of enrollment.

You may not qualify if…

• Unwillingness or inability to complete informed consent
• Lidocaine or Novocain allergy
• History of keloid formation
• Course of systemic antibiotics or antivirals within 2 weeks prior to enrollment.

Where it is running

• University of Rochester Medical Center — Rochester, New York, United States

Full record on ClinicalTrials.gov

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