Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)

Running, not enrolling

Conditions studied: Breast Cancer

In brief

This study will use advanced MRI techniques to characterize the changes that occur to the structure and functionality of the brain in older breast cancer patients receiving adjuvant chemotherapy, and determine the relationship between the brain changes and severity of chemotherapy toxicity. Our results will be an early step towards identifying neuroimaging markers of aging, breast cancer and chemotherapy treatment, and will contribute to our understanding of the underlying pathophysiology of cognitive changes and chemotherapy toxicity in vulnerable, older adults with cancer. Furthermore, the work will lay the foundation for future, larger scale clinical studies of cognitive changes and chemotherapy toxicity in the aging cancer population.

Key facts

Study ID

NCT01992432

Run by

City of Hope Medical Center

People needed

49

Starts

2013-09-30

Expected to finish

2026-11-30

Last updated by the study team

2026-01-28

Who can join

Age: 65 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 1) Patients with stage I-III breast cancers who are to receive adjuvant chemotherapy;
• 2) Able to understand English (the functional MRI task paradigms and neurocognitive testing are not validated in languages other than English);
• 3) Able to provide informed consent;
• 4) Patients age ≥ 65 and of any performance status.

You may not qualify if…

• 1) Patients with metastatic disease;
• 2) Patients with MRI exclusion criteria such as claustrophobia, cardiac pacemaker, and orbital metal implants.

Where it is running

• City of Hope Medical Center — Duarte, California, United States
• South Pasadena Cancer Center — South Pasadena, California, United States

Full record on ClinicalTrials.gov

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