A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Completed · Phase 3 · Has a placebo group

Conditions studied: Diabetes Mellitus, Type 2

In brief

The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.

Key facts

Study ID

NCT01991795

Run by

AstraZeneca

People needed

19271

Starts

2014-02-10

Expected to finish

2019-01-25

Last updated by the study team

2020-03-18

Who can join

Age: 50 and older, up to 130. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men or women ≥50 years of age with type 2 diabetes mellitus on treatment with a glucose lowering medication since at least 6 months, and either documented coronary artery occlusive disease or previous revascularization of a coronary artery.
• Key Exclusion Criteria:
• History of myocardial infarction or any stroke; planned treatment with agents inhibiting blood clotting; planned use of ASA/Aspirin at doses above 150 mg daily; planned coronary, cerebrovascular, or peripheral arterial revascularization; patients with known bleeding disorders and patients who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin; history of intracranial bleeding at any time, or a history of bleeding from the gastrointestinal tract within the last 6 months or a major surgery within the last 30 days; patients with known severe liver disease or with kidney failure requiring dialysis

Where it is running

• Research Site — Birmingham, Alabama, United States
• Research Site — Fairhope, Alabama, United States
• Research Site — Huntsville, Alabama, United States
• Research Site — Huntsville, Alabama, United States
• Research Site — Mobile, Alabama, United States
• Research Site — Montgomery, Alabama, United States
• Research Site — Sheffield, Alabama, United States
• Research Site — Tuscumbia, Alabama, United States
• Research Site — Cottonwood, Arizona, United States
• Research Site — Glendale, Arizona, United States
• Research Site — Tucson, Arizona, United States
• Research Site — Little Rock, Arkansas, United States
• Research Site — Little Rock, Arkansas, United States
• Research Site — Little Rock, Arkansas, United States
• Research Site — Anaheim, California, United States
• Research Site — Bakersfield, California, United States
• Research Site — Beverly Hills, California, United States
• Research Site — Fremont, California, United States
• Research Site — Fresno, California, United States
• Research Site — Irvine, California, United States
• Research Site — La Mesa, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Los Alamitos, California, United States
• Research Site — Alexander City, Alabama, United States

Full record on ClinicalTrials.gov

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