A Study of DNIB0600A in Comparison With Pegylated Liposomal Doxorubicin (PLD) in Participants With Platinum-Resistant Ovarian Cancer (PROC)

Stopped early · Phase 2

Conditions studied: Ovarian Cancer

In brief

This randomized, multicenter, open-label study will evaluate the safety and efficacy of DNIB0600A (RO5541081) in comparison with PLD in participants with PROC, primary peritoneal cancer or fallopian tube cancer. Participants will be randomized to receive either DNIB0600A 2.4 milligrams per kilogram (mg/kg) intravenously (IV) every 3 weeks or PLD 40 milligrams per meter-squared (mg/m\^2) IV every 4 weeks.

Key facts

Study ID

NCT01991210

Run by

Genentech, Inc.

People needed

95

Starts

2014-02-06

Expected to finish

2016-08-17

Last updated by the study team

2017-08-21

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Histologically documented epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer
• Advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer that has progressed or relapsed during or within 6 months after the most recent treatment with a platinum-containing chemotherapy regimen and for whom PLD is appropriate therapy
• No more than 1 prior cytotoxic chemotherapy regimens for the treatment of PROC and not more than 2 total regimens (defined as any therapy [approved or investigational] with intent to treat the ovarian cancer)
• Adequate hematologic, renal and liver function
• Willing and able to perform a patient-reported outcome (PRO) survey (including the possibility of using an electronic PRO device)
• For women of childbearing potential, agreement to use 1 highly effective form of contraception as defined by protocol through the course of study treatment and for 6 months after the last dose of study treatment

You may not qualify if…

• Primary platinum-refractory disease defined as disease progression during or within 2 months of a first-line, platinum-containing chemotherapy regimen
• Anti-tumor therapy, including chemotherapy, biologic, experimental, or hormonal therapy, within 4 weeks prior to Day 1
• Palliative radiation within 2 weeks prior to Day 1
• Prior anthracycline therapy, including prior treatment with PLD (for example, Doxil®, Caelyx®, or Lipodox®) in any setting (for example, in combination with carboplatin or as a single agent)
• Prior treatment with NaPi2b or SCL34A2 targeted therapy
• Major surgical procedure within 4 weeks prior to Day 1
• Current Grade greater than (>) 1 toxicity (except alopecia and anorexia) from prior therapy or Grade >1 neuropathy from any cause
• Left ventricular ejection fraction defined by multigated acquisition (MUGA)/echocardiogram below the institutional lower limit of normal
• Evidence of significant, uncontrolled, concomitant disease that could affect compliance with the protocol or interpretation of results, including significant cardiovascular disease or significant pulmonary disease
• Known active infection, or any major episode of infection requiring treatment with IV antibiotics or hospitalization (within 4 weeks prior to Cycle 1, Day 1)
• Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis
• Presence of positive test results for hepatitis B or hepatitis C as detailed in the protocol
• Known history of HIV seropositive status
• Other malignancy within the last 5 years, except for adequately treated carcinoma in situ of the cervix, squamous carcinoma of the skin, adequately controlled limited basal cell skin cancer, or synchronous primary endometrial cancer or prior primary endometrial cancer
• Untreated or active central nervous system metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control)
• Pregnancy or breastfeeding
• Known history of NaPi2b deficiency (for example, congenital alveolar microlithiasis or testicular microlithiasis)
• History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins)
• Metabolic dysfunction, physical examination finding, or clinical laboratory find giving reasonable suspicion of a disease or condition that contraindicated use of an investigational drug or may render the participant at high risk from treatment complications

Where it is running

• St. Joseph'S Hospital & Medical Center — Phoenix, Arizona, United States
• HonorHealth Research Institute - Pima Center — Scottsdale, Arizona, United States
• University of California Irvine Medical Center — Orange, California, United States
• Florida Cancer Specialists. — St. Petersburg, Florida, United States
• Hematology & Oncology Associates — Covington, Louisiana, United States
• Johns Hopkins Uni; Oncology Center — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Dana Farber Cancer Inst. — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Oklahoma University Health Sciences Center — Oklahoma City, Oklahoma, United States
• Northwest Cancer Specialists, P.C. — Tualatin, Oregon, United States
• Magee Womens Hospital — Pittsburgh, Pennsylvania, United States
• Women & Infants Hospital — Providence, Rhode Island, United States
• Sarah Cannon Cancer Center — Germantown, Tennessee, United States
• UZ Leuven Gasthuisberg — Leuven, Belgium
• CHU Sart-Tilman — Liège, Belgium
• London Regional Cancer Centre — London, Ontario, Canada
• Princess Margaret Hospital — Toronto, Ontario, Canada
• Chum Hopital Notre Dame; Centre D'Oncologie — Montreal, Quebec, Canada
• Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes — Lyon, France
• Hôpital Européen Georges Pompidou — Paris, France
• HOPITAL TENON; Cancerologie Medicale — Paris, France
• Institut Gustave Roussy — Villejuif, France
• Bialostockie Centrum Onkologi — Bialystok, Poland
• Wojewodzkie Centrum Onkologii — Gdansk, Poland

Full record on ClinicalTrials.gov

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