Eplerenone for the Treatment of Central Serous Chorioretinopathy

Completed · Not applicable · Has a placebo group

Conditions studied: Central Serous Chorioretinopathy

In brief

To test the effect oral eplerenone versus placebo in patients with central serious chorioretinopathy .

Key facts

Study ID

NCT01990677

Run by

Wills Eye

People needed

108

Starts

2013-10-01

Expected to finish

2015-05-01

Last updated by the study team

2018-11-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 and over
• Ability to give written informed consent
• Sub-retinal fluid under fovea seen on OCT
• Diagnosis of central serous chorioretinopathy (CSCR): classification is at the discretion of the investigator, but general guidelines are
• Acute- first episode or symptoms less than one month prior to presentation
• Chronic- previously documented sub-foveal fluid, any prior treatment, symptoms for over 3 months, or <50% reduction in fluid thickness on OCT after 3 months.

You may not qualify if…

• Age under 18
• Impaired decision-making ability
• At initial laboratory screening serum potassium >5.5 milliequivalent (mEq)/L
• At initial laboratory screening serum creatinine >2 mg/dL in men and >1.8 mg/dL in women or decreased renal function by creatinine clearance less than 50 mL/min
• Absence of sub-foveal fluid
• Any patient with prior treatment for CSCR within 3 months of enrollment
• Patients taking potassium supplements or potassium-sparing diuretics spironolactone, amiloride, and triamterene and/or potent CYP3A4 (cytochrome) inhibitors (amifostine, cyclosporine, fluconazole, itraconazole, ketoconazole, mifepristone, posaconazole, potassium salts, rituximab, tacrolimus, voriconazole nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)
• Women who are pregnant or are actively trying to conceive
• Patients with type 1 or type 2 diabetes

Where it is running

• Mid Atlantic Retina — Cherry Hill, New Jersey, United States
• Mid Atlantic Retina — Marlton, New Jersey, United States
• Mid Atlantic Retina — Mays Landing, New Jersey, United States
• Mid Atlantic Retina — Bala-Cynwyd, Pennsylvania, United States
• Mid Atlantic Retina — Bethlehem, Pennsylvania, United States
• Mid Atlantic Retina — Huntingdon Valley, Pennsylvania, United States
• Mid Atlantic Retina — Lansdale, Pennsylvania, United States
• Mid Atlantic Retina — New Wilmington, Pennsylvania, United States
• Mid Atlantic Retina — Newtown Square, Pennsylvania, United States
• Mid Atlantic Retina — Plymouth Meeting, Pennsylvania, United States

Full record on ClinicalTrials.gov

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