MRI Study of Radiation-Induced Damage to White Matter and Blood-Brain-Barrier
Completed
Conditions studied: Brain Neoplasms
In brief
This is a study to determine if Magnetic Resonance Imaging (MRI) techniques can detect early changes in white matter (in the brain) and the blood-brain barrier resulting from radiation therapy.
Key facts
- Study ID
- NCT01988675
- Run by
- University of Michigan Rogel Cancer Center
- People needed
- 91
- Starts
- 2004-08-26
- Expected to finish
- 2014-06-03
- Last updated by the study team
- 2018-06-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients receiving partial brain irradiation for malignant or benign brain tumors (including low-grade gliomas, high-grade gliomas, malignant meningioma, pituitary adenomas, supratentorial meningioma, or craniopharyngiomas); or patients receiving whole brain irradiation for brain metastases.
- Patients must be 18 years of age or older
- Patients must sign a study specific consent form approved by the Institutional Review Board (IRB) of the University of Michigan prior to study entry.
- Patients must have a neurological function class 1 or 2 with a Karnofsky performance status (a scoring system used to quantify general well being and quality of life on a scale of 100 to 0) of greater than or equal to 70.
- Patients must have an expected life expectancy of greater than 6 months.
You may not qualify if…
- Patients with a history of major medical illness or psychiatric impairment which, in the investigator's opinion, will prevent administration of the protocol.
- Patients who have had prior external beam irradiation to the brain or head/neck area that will lead to overlap of the radiation field.
- Patients should have no contraindications to having a contrast enhanced Magnetic Resonance Imaging (MRI) scan.
- Prisoners are excluded.
- Pregnant women are excluded.
Where it is running
- University of Michigan Hosptial — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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