Effects of Mifepristone on Biomarkers of Metabolic Function and Neuropsychological Performance Among Middle-Aged and Older Individuals

Completed · Phase 1

Conditions studied: Depression

In brief

The purpose of this study is to study the effect of cortisol,a stress hormone in the body, on memory and attention in people with a history of depression, but who are not in the midst of a current depressive episode. Cortisol may affect parts of the brain associated with memory and attention directly. It may also indirectly affect the brain by controlling how much insulin the body makes. Insulin is thought to impact cognition by changing the amount of sugar available in certain parts of the brain. The investigators are studying this question by giving patients a medication, called Mifepristone, which reduces cortisol's effect on the brain. The investigators will compare results from several groups of people, including differences between men and women, and between those with and without insulin resistance.

Key facts

Study ID

NCT01988610

Run by

Stanford University

People needed

23

Starts

2013-10-01

Expected to finish

2017-02-01

Last updated by the study team

2018-01-25

Who can join

Age: 50 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 50-70
• History of depression, not currently depressed.

You may not qualify if…

• History of type 1 or type 2 diabetes.
• Use of a medication that interacts with Mifepristone.

Where it is running

• Stanford University Psychiatry, 401 Quarry Rd — Stanford, California, United States

Full record on ClinicalTrials.gov

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