A Phase 2, Randomized, Double-blind, Placebo Controlled Dose Ranging Study of Repeat Doses of AA4500 for the Treatment of Edematous Fibrosclerotic Panniculopathy

Completed · Phase 2 · Has a placebo group

Conditions studied: Edematous Fibrosclerotic Panniculopathy (EFP)

In brief

To assess the safety and effectiveness of repeat doses of AA4500 in the treatment of edematous fibrosclerotic panniculopathy (EFP) commonly known as cellulite in adult women.

Key facts

Study ID

NCT01987986

Run by

Endo USA Inc., a Keenova Therapeutics Company

People needed

150

Starts

2013-10-01

Expected to finish

2014-08-01

Last updated by the study team

2017-10-05

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Be a female between 18 to 45 years of age.
• Have at least one well defined dimple that is at least 1 cm but not more than 2 cm along the long axis and that is evident when the subject is standing
• Have a photonumeric cellulite severity scale (CSS) score between 6 and 12
• Have a Body Mass Index (BMI) >19 and <30 kg/m2, and intends to maintain stable body weight throughout the duration of the study
• Be willing to apply appropriate sunscreen to the selected quadrant before each exposure to the sun while participating in the study
• Be judged to be in good health, based upon the results of a medical history, physical examination, and laboratory profile at screening.
• Have a negative urine pregnancy test at screening and before injection of AA4500 and be using an effective contraception method (ie, abstinence, intrauterine device [IUD], hormonal [estrogen/progestin] contraceptives, or barrier control) for at least one menstrual cycle prior to study enrollment and for the duration of the study.
• Be willing and able to cooperate with the requirements of the study.
• Voluntarily sign and date an informed consent agreement approved by the Institutional Review Board/Independent Ethics Committee/Human Research Ethics Committee (IRB/IEC/HREC).
• Be able to read, complete and understand the Patient Reported Outcomes rating instruments in English.

You may not qualify if…

• Thyroid disease, unless controlled with medication for ≥ 6 months
• Uncontrolled diabetes mellitus, as determined by the investigator
• Uncontrolled hypertension, as determined by the investigator
• Vascular disorder (eg, phlebitis or varicose veins) in area to be treated
• Lipedema or a lymphatic disorder
• Cushing's disease and/or use of systemic corticosteroids
• History of lower extremity thrombosis or post-thrombosis syndrome
• Documented autoimmune disorder such as lupus erythematosus, rheumatoid arthritis
• Inflammation or active infection in area to be treated
• Cutaneous alteration in area to be treated
• Rash, eczema, psoriasis, or skin cancer in the area to be treated
• History of keloidal scarring or abnormal wound healing
• Coagulation disorder
• Taking a medication for chronic anticoagulation (except for ≤ 150 mg aspirin daily)
• Known active hepatitis A, B or C
• Known immune deficiency disease or a positive test for human immunodeficiency virus (HIV)
• Other significant conditions including body dysmorphic disorder, which in the investigator's opinion would make the subject unsuitable for enrollment in the study
• Is menopausal defined as 12 months of amenorrhea in the absence of other biological or physiological causes, as determined by the investigator
• Has used any of the following for the treatment of EFP on the legs or buttock within the timelines identified below or intends to use any of the following at any time during the course of the study:
• Liposuction on the side of the body selected for treatment during the 12-month period before injection of AA4500
• Injections (eg, mesotherapy); radiofrequency device treatments; laser treatment; or surgery (including subcision) within the selected treatment quadrant during the 12-month period before injection of AA4500
• Endermologie or similar treatments within the selected treatment quadrant during the 6-months period before injection of AA4500
• Massage therapy within the selected treatment quadrant during the 3-month period before injection of AA4500
• Creams (eg, Celluvera™, TriLastin®) to prevent or mitigate EFP within the selected treatment quadrant during the 2-week period before injection of AA4500
• Has a tattoo located within 2 cm of the site of injection

Where it is running

• Dermatology Cosmetic Laser Medical Associates of La Jolla — San Diego, California, United States
• ATS Clinical Research — Santa Monica, California, United States
• Dermatology Research Institute — Coral Gables, Florida, United States
• Kenneth Beer, MD PA — West Palm Beach, Florida, United States
• Mercy Health Research — Washington, Missouri, United States
• Sadick Research Group — New York, New York, United States
• Stony Brook University Medical Center — Stony Brook, New York, United States
• Tennessee Clinical Research Center — Nashville, Tennessee, United States
• Charlottesville Dermatology — Charlottesville, Virginia, United States
• Premier Clinical Research — Spokane, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.