Identification of Adverse Plaque Characteristics by Coronary MR Angiography
Completed · Not applicable
Conditions studied: Coronary Artery Disease
In brief
This is a pilot study to determine whether coronary magnetic resonance angiography(CMRA)can identify adverse plaque characteristics (buildup of fat, cholesterol, calcium, and other substances found in the blood) seen on coronary computed tomography angiography(CCTA) and evaluate whether there is a relationship between the adverse plaque characteristics and the presence of coronary artery wall inflammation.
Key facts
- Study ID
- NCT01986868
- Run by
- Cedars-Sinai Medical Center
- People needed
- 2
- Starts
- 2012-04-01
- Expected to finish
- 2018-01-24
- Last updated by the study team
- 2021-01-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Ability to comprehend and sign informed consent
- Presence of a non-calcified or mixed plaque without high-grade stenosis in the left main or a proximal coronary artery segment AND at least one APC present in this plaque by CCTA (defined as LAP with <30 Hounsfield units or PR with ≥10% increase in the maximal vessel diameter within the plaque as compared to a proximal reference segment as previously described10).
You may not qualify if…
- High-grade stenosis (≥50% stenosis of the left main artery or ≥70% stenosis of another proximal coronary segment);
- Coronary artery stent in the segment with the reference plaque
- Possible pregnancy
- Glomerular filtration rate <45 ml/min
- More than 90 days between CCTA and CMRA study
- Any significant arrhythmia (e.g. atrial fibrillation, frequent ectopy)
- Significant asthma
- History of 2nd or 3rd degree heart block
- Allergy or known intolerance to beta-blockers
- Use of phosphodiesterase inhibitor (e.g. Viagra) within the last 48 hours
- Rapid heart rate (heart rate ≥90 beats/minute)
- Severe aortic stenosis (Aortic valve area <1.0 cm2 or mean gradient >30 mmHg)
- Systolic blood pressure <100 mmHg
- Other contraindication to MRI, including metallic implants (valve replacement, pacemaker, implantable cardiac defibrillator, metallic spine material), intracranial clips, metallic fragments in eyes, and claustrophobia
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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