Cisplatin vs Paclitaxel for Triple Negative Breast Cancer
Completed · Phase 2
Conditions studied: Triple Negative Breast Cancer
In brief
This is a phase II study randomizing patients with stage I with T1 \> 1.5 cm, stage II or III triple negative breast cancer (TNBC) to preoperative cisplatin versus paclitaxel. The study is designed to evaluate the ability of the Homologous Recombination Deficiency (HRD) assay to predict pathologic response to preoperative chemotherapy.
Key facts
- Study ID
- NCT01982448
- Run by
- Dana-Farber Cancer Institute
- People needed
- 147
- Starts
- 2014-04-01
- Expected to finish
- 2020-08-01
- Last updated by the study team
- 2025-09-30
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- University of Alabama — Birmingham, Alabama, United States
- Indiana University- Simon Cancer Center — Indianapolis, Indiana, United States
- Johns Hopkins University — Baltimore, Maryland, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- South Shore Hospital — Weymouth, Massachusetts, United States
- Memorial Sloan Kettering Cancer Center-Basking Ridge — Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Cancer Center-Monmouth — Middletown, New Jersey, United States
- Memorial Sloan Kettering Cancer Center-Commack — Commack, New York, United States
- Memorial Sloan Kettering Cancer Center-West Harrison — Harrison, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Center-Rockville Centre — Rockville Centre, New York, United States
- Memorial Sloan Kettering Cancer Center-Sleepy Hollow — Sleepy Hollow, New York, United States
- University of North Carolina- Lineberger Cancer Center — Chapel Hill, North Carolina, United States
- Duke University — Durham, North Carolina, United States
- Universtiy of Pittsburgh- Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
- Baylor College of Medicine — Houston, Texas, United States
- Seattle Cancer Alliance at EvergreenHealth — Kirkland, Washington, United States
- University of Washignton — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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