Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer

Stopped early

Conditions studied: Chronic Obstructive Pulmonary Disease, COPD

In brief

Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined. Since only 10% of heavy smokers develop lung cancer and 20% of lung cancers develop in nonsmokers, it is thought that genetic predisposition plays an important role. This study proposes to examine the genetic correlation between nasal and bronchial epithelium and to identify a patient's risk for lung cancer earlier.

Key facts

Study ID

NCT01982149

Run by

Weill Medical College of Cornell University

People needed

27

Starts

2014-06-01

Expected to finish

2019-05-01

Last updated by the study team

2020-07-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• HEALTHY VOLUNTEER RESEARCH SUBJECTS
• All study subjects should be able to provide informed consent
• Males or females ages 18 years and older
• Must provide HIV informed consent
• VOLUNTEER RESEARCH SUBJECTS WITH LUNG DISEASE
• Must provide informed consent
• Males and females age 18 years and older
• Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and/or (6) diseases of organs with known association with lung disease
• Must provide HIV informed consent

You may not qualify if…

• HEALTHY VOLUNTEER RESEARCH SUBJECTS
• Individuals not deemed in good overall health by the investigator will not be accepted into the study.
• Habitual use of drugs and/or alcohol within the past six months (Acceptable: - Marijuana one time in three months; average of two alcoholic beverages per day; drug and/or alcohol abuse is defined as per the DSM-IV Substance Abuse Criteria).
• Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.
• Individuals with allergies to atropine or any local anesthetic will not be accepted into the study.
• Individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study.
• Females who are pregnant or nursing will not be accepted into the study
• VOLUNTEER RESEARCH SUBJECTS WITH LUNG DISEASE
• Any history of allergies to xylocaine, lidocaine, versed, valium, atropine, pilocarpine, isoproterenol, terbutaline, aminophylline, or any local anesthetic will not be included in the study.
• Habitual use of drugs and/or alcohol within the past six months (Acceptable: Marijuana one time in three months; average of two alcoholic beverages per day; drug and/or alcohol abuse is defined as per the DSM-IV Substance Abuse Criteria)
• Females who are pregnant or nursing

Where it is running

• Weill Cornell Medical College and Weill Cornell Medical Center, Department of Genetic Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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