International Bicuspid Aortic Valve Consortium (BAVCon)
Running, not enrolling
Conditions studied: Bicuspid Aortic Valve Disease, Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve
In brief
Bicuspid aortic valve (BAV) disease is the most frequent congenital cardiac malformation, occurring in 0.5-1.2% of the US population. In young adults, it is generally a benign abnormality; but in older adults it is associated with thoracic aortic aneurysm or dissection in 20-30% of those with BAV. BAV is strongly associated with early development of aortic valve calcification or incompetence in \>50% of BAV patients, and accounts for \~40% of the \>30,000 aortic valve replacements (AVR) performed in the US each year. Yet, we know little of the etiology, cellular events and modifiers of progression of BAV to calcific aortic valve disease and we still do not understand the genetic cause(s) of BAV despite evidence for its high heritability. The Specific Aims of this study are: 1. To identify the genetic causes of bicuspid aortic valve disease and its associated thoracic aortic disease. 2. To identify potential pathways to predict the clinical course of BAV disease and for treating human BAV disease. To achieve these aims, we have created the International Bicuspid Aortic Valve Consortium (BAVCon), a consortium of institutions with cohorts of BAV patients and the expertise to fulfill the performance of these aims.
Key facts
- Study ID
- NCT01980797
- Run by
- Boston University
- People needed
- 6464
- Starts
- 2013-11-01
- Expected to finish
- 2028-11-01
- Last updated by the study team
- 2026-04-01
Who can join
Age: 8 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed as having a bicuspid aortic valve
- All ages ≥8 years
- Able to provide fully informed consent
You may not qualify if…
- None
Where it is running
- Tufts Medical Center — Boston, Massachusetts, United States
- Boston Medical Center — Boston, Massachusetts, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Mayo Clinic — Rochester, Minnesota, United States
- University of Texas Health Science Center at Houston — Houston, Texas, United States
- Laval University — Québec, Quebec, Canada
- Istituto Policlinico San Donato — San Donato Milanese, Milan, Italy
- Monaldi Hospital — Naples, Italy
- Second University of Naples — Naples, Italy
- University of Salerno — Salerno, Italy
- Hospital Vall d'Hebron — Barcelona, Spain
- University of Oxford — Oxford, United Kingdom
Full record on ClinicalTrials.gov
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