Establishing and Eliminating Cue-drug Associations in Human Cocaine Addiction
Stopped early · Phase 1 · Has a placebo group
Conditions studied: Cocaine Dependent Subjects
In brief
We will develop a procedure for conditioning cue-cocaine associations in human drug users. Next, we will reactivate that learning and intervene pharmacologically to prevent the reconsolidation of cue-drug memories. We hypothesize that a combined behavioral and pharmacological approach will have significant potential for persistently inhibiting relapse.
Key facts
- Study ID
- NCT01978457
- Run by
- Yale University
- People needed
- 6
- Starts
- 2012-10-01
- Expected to finish
- 2019-12-01
- Last updated by the study team
- 2020-03-02
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 - 50 years
- voluntary, written, informed consent
- physically healthy by medical history, physical, neurological, ECG, and laboratory examinations
- DSM-IV criteria for Cocaine Abuse (305.60) or Cocaine Dependence (304.20)
- recent street cocaine use in excess of that administered in the current study
- intravenous and/or smoked (crack/freebase) use
- positive urine toxicology screen for cocaine
- for females, non-lactating, no longer of child-bearing potential (or agree to practice effective contraception during the study), and a negative serum pregnancy (-HCG) test
- able to read English and complete study evaluations.
You may not qualify if…
- Other drug dependence (except nicotine)
- a primary major DSM-IV psychiatric diagnosis (schizophrenia, bipolar disorder, etc.), unrelated to cocaine
- a history of significant medical (cardiovascular) or neurological illness (e.g., prior myocardial infarction, current active symptoms of cardiovascular disease / angina, evidence of cocaine-related cardiovascular symptoms, prior arrythmias of clinical significance, and/or need for cardiovascular resuscitation, neurovascular events such as transient ischemic attacks, stroke, and/or seizures)
- current use of psychotropic and/or potentially psychoactive prescription medication
- seeking treatment for drug abuse/dependence
- those having contraindications to beta-blocker administration, including diagnoses of asthma, bronchitis, emphysema, or a history of adverse reactions to beta-blockers (including propranolol), as well as those with bradycardia and/or first-degree or greater heart block by ECG
Where it is running
- Connecticut Mental Health Center — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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