Brain Mechanisms of Human Motivation
Completed
Conditions studied: Major Depressive Disorder, Bipolar Disorder
In brief
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
Key facts
- Study ID
- NCT01976975
- Run by
- Mclean Hospital
- People needed
- 270
- Starts
- 2013-10-01
- Expected to finish
- 2018-01-01
- Last updated by the study team
- 2021-08-04
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Written informed consent
- Right-handed
- (For mood disorder group only) Stable medication over the past 8 weeks OR absence of any psychotropic medications for at least 2 weeks (for follow-up analyses testing effects in medication-free patients):
- 6 weeks for fluoxetine,
- 6 months for neuroleptics,
- 2 weeks for benzodiazepines,
- 2 weeks for any other antidepressants
- 4 weeks for any mood-stabilizers
You may not qualify if…
- Suicidal ideation where outpatient treatment is determined unsafe by the study clinician
- Pregnant women or women of childbearing potential who 1) have not completed a negative urine pregnancy test prior to the MRI scan and/or 2) are seeking to become pregnant or believe that they may be pregnant
- Serious/unstable medical illness (e.g., cardiovascular, renal, endocrine, neurologic disease)
- Clinical or laboratory evidence of hypothyroidism
- History of seizure disorder, history or current diagnosis of dementia, score < 26 on the MMSE at screening
- History or current diagnosis of the following DSM-IV psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorder NOS, patients with mood congruent or mood incongruent psychotic features, anorexia nervosa, obsessive compulsive disorder
- Lifetime history of stimulant dependence (e.g., cocaine, amphetamines)
- Current use of Methylphenidate (Ritalin) and other ADHD medications with dopaminergic effects
- Patients with a lifetime history of electroconvulsive therapy (ECT)
- Failure to meet standard MRI safety requirements
Where it is running
- McLean Hospital — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
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