Chlorhexidine Gluconate Versus Povidone Iodine at Cesarean Delivery: a Randomized Controlled Trial

Completed · Not applicable

Conditions studied: Pregnancy, Cesarean Section

In brief

Currently there are no published studies comparing the efficacy of Chloraprep and povidone-iodine in decreasing postoperative- wound infection in cesarean sections. However, there have been studies involving other types of surgery that have compared the efficacy of different types of preoperative cleansing agents in preventing postoperative wound infection. These studies have shown that controversy exists over which antiseptic skin preparation is the most effective for preventing postoperative surgical wound infections. The standard of care at Los Angeles County Hospital for preoperative skin antiseptic in cesarean sections is povidone- iodine 10% (betadine), however many other hospitals have made the transition to using Chloraprep. In an attempt to improve on the current standard of care, we propose a quality improvement prospective randomized study to compare the difference in postoperative wound complications with the use of povidone- iodine and Chloraprep as a preoperative antiseptic in cesarean sections. We hypothesize that Chloraprep will be better than Betadine at reducing the incidence of positive bacterial cultures following cesarean sections.

Key facts

Study ID

NCT01975805

Run by

University of Southern California

People needed

60

Starts

2010-01-01

Expected to finish

2012-05-01

Last updated by the study team

2013-11-05

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pregnant women greater than 36 weeks gestation presenting for scheduled repeat cesarean sections and scheduled primary cesarean sections
• Ages 18-45
• Written informed consent obtained

You may not qualify if…

• Patients who are taking antimicrobial therapy for any reason
• Patient with a known allergy to one or both of the prepping agents
• Patients currently taking immunosuppressant drugs
• Active acute or chronic infection
• Current history of cancer
• Open wounds, skin ulcers, sores, and severe acne
• History of methicillin-resistant staphylococcus aureus colonization or oxacillin-resistant staphylococcus aureus colonization

Where it is running

• University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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