Neuroendocrine and Immune Response to Stress in Schizophrenia

Completed · Not applicable

Conditions studied: Schizophrenia, Schizoaffective Disorder

In brief

This is a pilot study. We are testing the physiologic, immune and chemical responses to stress. We believe the results of all measures to stress will be blunted in schizophrenia compared to healthy controls. We will test sex, early life stress and other factors on the relationship to a stress response.

Key facts

Study ID

NCT01975584

Run by

University of Maryland, Baltimore

People needed

21

Starts

2013-09-01

Expected to finish

2018-06-01

Last updated by the study team

2019-09-27

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• DSM-IV diagnosis of schizophrenia or schizoaffective disorder (schizophrenia group)
• No DSM-IV Axis I or II disorder (healthy control group)
• Caucasian or Non-Caucasian

You may not qualify if…

• History of Cushing's syndrome, adrenal deficiency, or any condition that may affect cortisol levels in the body.
• Use of steroids
• Pregnancy or lactation. Pregnancy will be determined by urine pregnancy test. Lactation will be determined through patient report.
• Untreated hypertension, cardiac arrthymias or medical condition that could not handle stress.

Where it is running

• Maryland Psychiatric Research Center — Catonsville, Maryland, United States

Full record on ClinicalTrials.gov

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