Seizure Prophylaxis in Aneurysm Repair

Stopped early · Phase 4

Conditions studied: Intracranial Aneurysms, Seizures

In brief

Seizures are a potential complication of surgical repair of intracranial aneurysms. In order to prevent seizures, many surgeons administer prophylactic anti-epileptic medication during the intra-operative and post-operative period, however, such practice is not supported by clinical data. Retrospective review found the incidence of postoperative seizures was higher in those who received anti-epileptics versus those who did not. The goal is to examine the utility of levetiracetam (Keppra) for seizure prophylaxis in patients undergoing surgical repair of unruptured intracranial aneurysms.

Key facts

Study ID

NCT01974700

Run by

Indiana University

People needed

17

Starts

2013-07-01

Expected to finish

2016-02-01

Last updated by the study team

2016-03-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (≥18 years)
• Presence of intracranial aneurysm (without rupture)
• Treating surgeon has recommended surgical repair of the aneurysm.

You may not qualify if…

• History of seizures within last 10 years
• History of epilepsy
• History of prior stroke
• Currently prescribed medication with anti-epileptic activity (keppra,dilantin, tegretol, lamictal, topamax, etc.)
• Brain tumor
• Pregnant or nursing woman
• Known levetiracetam allergy

Where it is running

• IU Health Methodist Hospital — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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