ICON1: Treatment Decisions and Outcomes in Pediatric Refractory ITP

Completed

Conditions studied: Immune Thrombocytopenia

In brief

The purpose of this study is to understand physician treatment decisions in selecting specific second line treatments in pediatric ITP and to determine the effectiveness of different second line ITP treatments. Eligible patients are those ages 1-18 years who are starting on a new second line treatment for ITP, defined as any treatment other than IVIG, steroids, anti-D globulin, or aminocaproic acid. Enrolled patients remain on the study for approximately one year.

Key facts

Study ID

NCT01971684

Run by

Boston Children's Hospital

People needed

120

Starts

2013-08-01

Expected to finish

2017-04-01

Last updated by the study team

2020-05-21

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Immune Thrombocytopenia or Evans Syndrome
• Ages > 12 months to <18 years
• Starting a new second line therapy as defined as any therapy except IVIG, steroids, anti-D globulin, or aminocaproic acid
• Starting a single agent/monotherapy

You may not qualify if…

• Evans Syndrome with a history of or current evidence of autoimmune hemolytic anemia
• Unwillingness to be followed for 1 year
• Physician providing care is unwilling to participate
• Patient is starting multiple second line agents simultaneously

Where it is running

• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• Mattel Children's Hospital — Los Angeles, California, United States
• Children's Hospital of Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lucile Packard Children's Hospital — Palo Alto, California, United States
• UC Davis Medical Center — Sacramento, California, United States
• UCSF School of Medicine — San Francisco, California, United States
• Colorado Children's Hospital — Denver, Colorado, United States
• Children's Healthcare of Atlanta — Atlanta, Georgia, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• James Whitcomb Riley Hospital for Children — Indianapolis, Indiana, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• St. John Hospital & Medical Center — Detroit, Michigan, United States
• Goryeb Children's Hospital — Morristown, New Jersey, United States
• Columbia University Medical Center — New York, New York, United States
• New York-Presbyterian University Hospital of Columbia and Cornell — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Cincinnati Children's Hospital — Cincinnati, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• Oregon Health and Sciences University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Hasbro Children's Hospital — Providence, Rhode Island, United States
• St. Jude's Hospital — Memphis, Tennessee, United States
• University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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