Stress CT Perfusion in Patients With Chest Pain

Completed · Not applicable

Conditions studied: Coronary Artery Disease

In brief

Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying hemodynamically significant coronary stenosis, aid in the identification of individuals most likely to benefit from revascularization, and thus improve the ability to predict patient outcomes. Our goals are: 1. to test the above hypothesis by comparing stress MDCT perfusion data with invasive fractional flow reserve (FFR) data in patients with significant stenosis who undergo ICA; 2. to determine the added value of MDCT perfusion as an adjunct to CTCA for predicting patient outcomes.

Key facts

Study ID

NCT01969916

Run by

University of Chicago

People needed

150

Starts

2014-06-01

Expected to finish

2018-06-01

Last updated by the study team

2021-02-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with chest pain referred for CT coronary angiography

You may not qualify if…

• allergy to iodine,
• renal dysfunction (creatinine >1.6 mg/dL)
• chronic obstructive pulmonary disease
• advanced heart block
• or systolic blood pressure <90 mmHg

Where it is running

• University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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