Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine Abuse
Completed · Early Phase 1 · Has a placebo group
Conditions studied: Methamphetamine Abuse, Methamphetamine Dependence
In brief
The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, oxazepam (Serax®) and naltrexone (Revia®), as a pharmacotherapy for methamphetamine (Desoxyn®) dependence. A rigorous, inpatient human laboratory study will be conducted. The proposed study is innovative and important because it will provide the impetus for the conduct of double blind, placebo-controlled trials to further demonstrate the efficacy of combined oxazepam and naltrexone for managing methamphetamine dependence.
Key facts
- Study ID
- NCT01967381
- Run by
- University of Kentucky
- People needed
- 24
- Starts
- 2013-10-01
- Expected to finish
- 2018-09-01
- Last updated by the study team
- 2018-09-14
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Lifetime methamphetamine use
You may not qualify if…
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to methamphetamine (Desoxyn®), oxazepam (Serax®) or naltrexone (Revia®)
Where it is running
- University of Kentucky Medical Center — Lexington, Kentucky, United States
Full record on ClinicalTrials.gov
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