Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer
Completed · Phase 1
Conditions studied: EGFR-Mutant Lung Cancer
In brief
The purpose of this study is to test the safety of different ways of taking erlotinib. The investigators want to find out what effects, good and/or bad, combination daily low dose and twice weekly high dose erlotinib has on the patient and lung cancer. The investigators are also seeing whether different schedules of erlotinib are better at treating lung cancer that has spread to the central nervous system. CNS expansion phase: The pulse continuous regimen will be then assess in patients with EGFR mutant lung cancers and CNS involvement. An additional expansion cohort (A) will enroll 19 patients with newly diagnosed EGFR mutant lung cancer with CNS involvement at diagnosis. The patients in the expansion cohorts will undergo the same treatment plan as the patients in the dose expansion cohort. A patient in the expansion cohorts will not be replaced if he/she does not finish the first 28 day (cycle 1) treatment period.
Key facts
- Study ID
- NCT01967095
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 53
- Starts
- 2013-10-15
- Expected to finish
- 2018-11-08
- Last updated by the study team
- 2018-11-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- MSKCC pathologically-proven diagnosis locally advanced Stage III not amenable to definitive, curative treatment or Stage IV or recurrent non-small cell lung cancer
- Documented presence of EGFR mutation confirmed by MSKCC or a local facility.
- No prior treatment with erlotinib, gefitinib, or other EGFR tyrosine kinase inhibitors
- Age ≥ 18 years
- Measurable (RECIST 1.1) indicator lesion not previously irradiated.
- Karnofsky Performance Status ≥ 70%
- Ability to take oral medications
- A negative serum pregnancy test obtained within 4 weeks prior to the start of treatment in all women of child-bearing potential.
- All women of child bearing potential and sexually active men must agree to use adequate methods of birth control throughout the study which includes use of oral contraceptives with an additional barrier methods, double barrier methods, Depo-Provera, permanent sterilization of patient or partner or total abstinence.
- Expansion A:
- brain metastases or leptomeningeal not previously treated with radiation or surgery
You may not qualify if…
- Inadequate recovery from any toxicity related to prior treatment (to Grade 2 or baseline).
- Inadequate hematologic function defined as ANC < 1000 cells/mm³, Platelet count <75,000/mm³ or Hemoglobin <9.0g/dL.
- Inadequate hepatic function defined by AST/ALT >3x upper limit of normal (ULN), Total bilirubin>2x ULN, Alkaline phosphatase >3x ULN.
- Symptomatic brain metastasis requiring radiation therapy or escalating doses of steroids.
- Patients with clinically stable brain metastases or leptomeningeal disease (previously treated or untreated) are eligible. Patients in expansion cohort A must have at least one untreated CNS lesion
- Women who are breastfeeding or pregnant.
- Any evidence of clinically active interstitial lung disease.
Where it is running
- Memoral Sloan Kettering Cancer Center — Basking Ridge, New Jersey, United States
- Memorial Sloan Kettering Commack — Commack, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Memorial Sloan Kettering Rockville Centre — Rockville Centre, New York, United States
- Memoral Sloan Kettering Cancer Center at Phelps — Sleepy Hollow, New York, United States
Full record on ClinicalTrials.gov
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