Improving Anticoagulant Therapy Through Warfarin Metabolite Profiling
Completed
Conditions studied: Stable Target INR
In brief
Clinically relevant biomarkers for warfarin identified in this study will provide crucial leads for subsequent studies to assess their predictive value during anticoagulant therapy. This knowledge will aid stratifying risk among patients to improve therapeutic outcomes and decrease adverse drug events and associated health care costs. Collectively, these efforts will provide a critical foundation for future research using a metabolite biomarker strategy in a clinical setting to revolutionize warfarin therapy. Through its application, a real-time assessment of warfarin metabolism for each patient could lead to a truly personalized dosing strategy and improve patient safety for this life-saving drug.
Key facts
- Study ID
- NCT01964794
- Run by
- University of Arkansas
- People needed
- 60
- Starts
- 2012-05-01
- Expected to finish
- 2016-10-01
- Last updated by the study team
- 2016-10-07
Who can join
Age: 60 and older, up to 69. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Males aged 60 - 69 originally. Opened inclusion criteria age to include 18-79 years of age.
- Potential participant received a warfarin maintenance dose with a stable INR (defined as within target range over a two month (60 day) period that includes a minimum of two clinical visits).
- Potential participant has taken warfarin as prescribed over the past three days.
You may not qualify if…
- Female
- Potential participant receiving a warfarin while not achieving a stable INR (defined as within target range over a two month (60 day) period that includes a minimum of two clinical visits).
- Potential participant has not received any warfarin over the past three days.
Where it is running
- Central Arkansas Veterans Healthcare System — Little Rock, Arkansas, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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