Galectin-3 Blockade in Patients With High Blood Pressure

Completed · Not applicable · Has a placebo group

Conditions studied: Hypertension

In brief

This study will investigate if Modified Citrus Pectin (MCP) can help people with high blood pressure. MCP is a dietary supplement that is derived from plants, and therefore is not subject to approval by the U.S. Food and Drug Administration (FDA). However, MCP has been deemed as 'generally regarded as safe' by the FDA. This study will examine whether Modified Citrus Pectin (MCP) can help people with high blood pressure. The study will help understand how MCP may affect the risk for heart disease in patients with high blood pressure.

Key facts

Study ID

NCT01960946

Run by

Massachusetts General Hospital

People needed

59

Starts

2013-10-01

Expected to finish

2018-08-30

Last updated by the study team

2021-02-21

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21-70 years
• Physician diagnosed hypertension on stable therapy for 3 months
• Elevated galectin-3 level (above sex-specific median based on Framingham Heart Study measures)
• Able to understand the protocol and provide informed consent in English

You may not qualify if…

• Uncontrolled hypertension, defined as systolic blood pressure > 170mmHg, diastolic blood pressure > 100mmHg
• Evidence of secondary hypertension
• History of heart failure, coronary artery disease, stroke, atrial fibrillation
• Left ventricular ejection fraction < 45% on echocardiography
• Use of aldosterone antagonists
• History of liver cirrhosis
• History of pulmonary fibrosis
• Kidney dysfunction, defined as estimated glomerular filtration rate < 45 ml/min/1.73m2
• Anemia, defined as hematocrit < 37% in men and < 34% in women
• Use of chelating agents
• History of Active cancer or malignancy
• Known pregnancy, those unwilling to avoid pregnancy during the course of the study, or women currently breastfeeding
• Hyperkalemia on screening labs, defined as potassium >5.2
• Anticipated inability to complete or comply with study protocol
• History of angioedema

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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