Does Continued Use of Clopidogrel Into Surgery Cause Increased Perioperative Bleeding?

Completed · Phase 2

Conditions studied: Clopidogrel

In brief

Patients who on taking clopidogrel are randomized to either continue clopidogrel into general surgery or discontinue clopidogrel 7 days before surgery. All patients resume clopidogrel after surgery. The investigators track the development of bleeding complications that may develop within 90 days of the surgery. Patients are medically cleared to be in either arm of the study by their cardiologist and surgeon. There is currently no evidence to support for or against the use continuation or discontinuation of clopidogrel prior to general surgery.

Key facts

Study ID

NCT01960296

Run by

Icahn School of Medicine at Mount Sinai

People needed

48

Starts

2012-01-01

Expected to finish

2013-05-01

Last updated by the study team

2017-05-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• taking clopidogrel
• undergoing general surgery
• cleared by both cardiologist and surgery for randomized arm

You may not qualify if…

• previous history of bleeding complications/bleeding disposition
• no capacity to consent

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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