The Effect of AGE on the Immune System

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

This is a nutritional intervention study using healthy overweight/obese humans to investigate if a supplement made from aged garlic extract has an impact on immunity. Following a baseline blood draw, participants will consume the capsules (garlic or placebo) for 42 days, at which time a second blood draw will occur. Tests for immune function and inflammation will be performed on both the baseline and 42 day samples. The investigators anticipate that the immune functions and biomarkers that are inflammatory in an overweight/obese population will be returning to normal after 42 days of consumption of this supplement. The investigators predict that AGE supplementation will benefit immunity and improve function while reducing inflammation in a stressed population (inflamed obese).

Key facts

Study ID: NCT01959646
Run by: University of Florida
People needed: 91
Starts: 2014-01-01
Expected to finish: 2015-11-01
Last updated by the study team: 2016-02-26

Who can join

Age: 25 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

ages 25-65
BMI > or = to 30 kg/m2
willing to discontinue dietary supplements
cRP between 2 and 10 mg/L

You may not qualify if…

medication for hypertension, high cholesterol, heart failure, angina, etc
diagnoses of diabetes, metabolic syndrome, arthritis, severe allergies, or any other compromised immune condition
blood pressure > 135/85 mmHg
serum triglycerides > 150 mg/dl
HDL cholesterol < 40 mg/dl for men or < 50 mg/dl for women
fasting glucose > 110 mg/dl

Where it is running

Food Science & Human Nutrition Building, University of Florida — Gainesville, Florida, United States
University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.