Optimal Dose of Early Intervention to Prevent PTSD

Completed · Not applicable

Conditions studied: Posttraumatic Stress Disorder

In brief

The overall aim of this study is to determine the optimal dose, 3-session exposure intervention versus 1-session exposure intervention compared to no treatment, for the delivery of exposure therapy in the immediate aftermath of trauma for preventing the development of posttraumatic stress disorder.

Key facts

Study ID

NCT01959620

Run by

Emory University

People needed

95

Starts

2013-10-01

Expected to finish

2016-12-01

Last updated by the study team

2017-07-21

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presenting to the emergency department of Emory University School of Medicine/Grady Memorial Hospital for trauma in the past 72 hours
• Meets DSM-IV diagnostic criterion A in which both of the following are present: (i) The person experienced, witnessed, or was confronted with an event or events that involved actual or threatened death or serious injury or a threat to the physical integrity of self or others (ii) The person's response involved intense fear, helplessness, or horror
• Speaks and understands spoken English
• Have a memory of what happened during the trauma
• Can see the assessment forms, hear instructions, and function at an emotional and intellectual level sufficient to allow accurate completion of all assessment instruments

You may not qualify if…

• Current or history of mania, schizophrenia, or other psychoses
• Current (past month) prominent suicidal ideation or recent (past 3 months) parasuicidal behavior or other self-injurious behavior, such as low lethality cutting
• Current (past month) substance dependence; people who meet criteria for current substance abuse but not dependence, or past dependence and have been in remission for at least 1 month are eligible
• Experienced a loss of consciousness for more than 5 minutes as a result of injuries sustained during the trauma
• Intoxicated, altered, or highly distressed to the degree that accurate completion of the study assessments or participation in study procedures is not possible
• Blood alcohol level above .08, determined by breathalyzer in the emergency department
• Not alert, oriented, and coherent
• In severe pain, active labor, or respiratory distress or hemodynamically compromised in any way

Where it is running

• Grady Memorial Hospital, Emergency Department — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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