S1313, PEGPH20 in Treating Patients With Newly Diagnosed Metastatic Pancreatic Cancer
Completed · Phase 1/Phase 2
Conditions studied: Metastatic Pancreatic Adenocarcinoma
In brief
This partially randomized phase I/II trial studies the side effects and best dose of pegylated recombinant human hyaluronidase (PEGPH20) when given together with combination chemotherapy and to see how well they work compared with combination chemotherapy alone in treating patients with newly diagnosed pancreatic cancer that has spread to other places in the body. Pegylated recombinant human hyaluronidase may help chemotherapy drugs work better by making tumor cells more sensitive to the drugs. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination chemotherapy is more effective with or without pegylated recombinant human hyaluronidase in treating pancreatic cancer.
Key facts
- Study ID
- NCT01959139
- Run by
- SWOG Cancer Research Network
- People needed
- 126
- Starts
- 2014-01-23
- Expected to finish
- 2023-11-09
- Last updated by the study team
- 2024-02-09
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- University of Arizona Cancer Center-North Campus — Tucson, Arizona, United States
- The University of Arizona Medical Center-University Campus — Tucson, Arizona, United States
- Sutter Auburn Faith Hospital — Auburn, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
- Alta Bates Summit Medical Center-Herrick Campus — Berkeley, California, United States
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California, United States
- Mills - Peninsula Hospitals — Burlingame, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
- Eden Hospital Medical Center — Castro Valley, California, United States
- City of Hope Corona — Corona, California, United States
- UC Irvine Health Cancer Center-Newport — Costa Mesa, California, United States
- Sutter Davis Hospital — Davis, California, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Los Angeles County-USC Medical Center — Los Angeles, California, United States
- USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Fremont - Rideout Cancer Center — Marysville, California, United States
- Memorial Medical Center — Modesto, California, United States
- Palo Alto Medical Foundation-Camino Division — Mountain View, California, United States
- Palo Alto Medical Foundation-Gynecologic Oncology — Mountain View, California, United States
- Sutter Cancer Research Consortium — Novato, California, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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