NOVOCART®3D for Treatment of Articular Cartilage of the Knee
Running, not enrolling · Phase 3
Conditions studied: Articular Cartilage of the Femoral Condyle Between 2-6cm2
In brief
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Key facts
- Study ID
- NCT01957722
- Run by
- Aesculap Biologics, LLC
- People needed
- 233
- Starts
- 2013-12-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-03-21
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Greater than 18 years old
- Isolated articular cartilage lesions on the femoral condyle 2-6 cm2
- Minimum score on the KOOS questionnaire
You may not qualify if…
- Instability of the knee joint
- Arthritis
- Autoimmune disease
- Immune suppression
- Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture (debridement and lavage are acceptable beyond three months from baseline)
- Bone disease
- Any degenerative muscular, connective tissue or neurological condition or other disease process that would interfere with healing or the evaluation of outcome measures.
Where it is running
- Grossmont Orthopaedic Medical Group — La Mesa, California, United States
- UCLA — Los Angeles, California, United States
- Stanford Medicine — Redwood City, California, United States
- Cu Sports Medicine — Denver, Colorado, United States
- Yampa Valley Medical Center — Steamboat Springs, Colorado, United States
- Tenet Florida Physician Services — Boca Raton, Florida, United States
- Paley Orthopedic and Spine Institute — West Palm Beach, Florida, United States
- Saint Alphonsus Medical Group — Meridian, Idaho, United States
- Rush University Medical Center — Chicago, Illinois, United States
- Northshore University Health System — Evanston, Illinois, United States
- University of Kentucky — Lexington, Kentucky, United States
- Ochsner Health System — New Orleans, Louisiana, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Tria Orthopaedic Center — Bloomington, Minnesota, United States
- Mayo Clinic — Rochester, Minnesota, United States
- University of Missouri Healthcare — Columbia, Missouri, United States
- Mount Sinai Faculty Practice Associates — New York, New York, United States
- Plancher Orthopaedics & Sports Medicine — New York, New York, United States
- Long Island Bone and Joint Llp — Port Jefferson, New York, United States
- Ohio State University Sports Medicine — Columbus, Ohio, United States
- Tulsa Bone and Joint Associates — Tulsa, Oklahoma, United States
- St. Luke'S University Health Network — Bethlehem, Pennsylvania, United States
- Penn State Hershey Medical Center — Hershey, Pennsylvania, United States
- Temple University Hospital — Philadelphia, Pennsylvania, United States
- Allegheny - Singer Research Institute — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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