Detecting Depression and Bipolar Disorder in Adolescents Using a Biomarker Panel
Stopped early
Conditions studied: Major Depressive Disorder, Bipolar Disorder, Serum Biomarkers
In brief
Depression and bipolar disorder are major public health concerns for adolescents today. Teenage depression and bipolar disorder are associated with social isolation, family stress, school failure, substance abuse and suicide. Screening for depression and bipolar disorder so that treatment can be started early in the course of illness is an urgent public health priority. Many teens with bipolar disorder are incorrectly diagnosed as having unipolar depression. It is critical that adolescents receive proper screening and assessment that leads to an accurate diagnosis and treatment. An efficient, cost-effective, blood-based screening program could be performed on an annual or semi-annual basis to potentially detect depression and then differentiate between unipolar and bipolar depression. If this type of screening were able to detect a significant percentage of teens with depression or bipolar disorder, the positive impact on U.S. public health would be substantial. The purpose of this study is to conduct a pilot study to assess the probability of detecting adolescent unipolar and bipolar depression through blood samples.
Key facts
- Study ID
- NCT01957501
- Run by
- University of Utah
- People needed
- 75
- Starts
- 2013-07-01
- Expected to finish
- 2016-03-01
- Last updated by the study team
- 2017-04-10
Who can join
Age: 13 and older, up to 21. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Exclusion of Major Depressive Disorder and Bipolar Disorder Participants:
- Meet the DSM-IV criteria for substance abuse or dependence in the last month
- History of fainting or other significant adverse event during blood draws in the past
- Dysthymia
- Daily use of oral or inhaled steroids
- High risk of suicidal behaviors, homicidal behaviors, or self-harm
- A medical condition, such as Addison's Disease, which is highly likely to influence the inflammatory or HPA responses
- Exclusion of Healthy Control Participants:
- Clinically significant psychiatric or substance abuse disorder
- Unstable medical or neurological illness
- History of fainting or other significant adverse event during blood draws in the past
- Daily use of oral or inhaled steroids
- A medical condition, such as Addison's Disease, which is highly likely to influence the inflammatory or HPA responses
Where it is running
- University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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