Propranolol in Severely Burned Children

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Burn

In brief

To determine the safety and efficacy of administration of propranolol for reducing heart rate and blood pressure in burn injury.

Key facts

Study ID

NCT01957449

Run by

The University of Texas Medical Branch, Galveston

People needed

63

Starts

2013-12-01

Expected to finish

2019-04-23

Last updated by the study team

2019-09-24

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burns covering >20% of the total body surface are
• Age of 0 to 18 years
• Patient arrival to the burn center within 96 hours (4 days) of burn injury
• Require > 1 surgical procedure

You may not qualify if…

• Pregnancy
• Known history of AIDS, Aids Related Complex, or HIV
• History of cancer within 5 years
• Existence of pre-morbid conditions
• Asthma
• Congestive heart failure (measured ejection fraction < 20%)
• Medical condition requiring glucocorticoid treatment
• Burn injury due to chemical burns
• Burn injury due to deep electrical injury (decision of hospital PI)
• Presence of anoxic brain injury that is not expected to result in complete recovery
• Decision not to treat due to burn injury severity

Where it is running

• Shriners Hospitals for Children — Sacramento, California, United States
• Shriners Hospitals for Children — Boston, Massachusetts, United States
• Shriners Hospitals for Children — Cincinnati, Ohio, United States
• Shriners Hospitals for Children — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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