Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.

Completed · Phase 1 · Has a placebo group

Conditions studied: Insulin Resistance, Prediabetic State

In brief

This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.

Key facts

Study ID

NCT01956929

Run by

Mayo Clinic

People needed

12

Starts

2013-10-01

Expected to finish

2016-03-01

Last updated by the study team

2017-09-01

Who can join

Age: 35 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 35-65 years of age
• Fasting blood glucose >100 mg/dl
• BMI 27-36 kg/m2
• Waist Circumference: Men ≥ 104 cm; women ≥ 88 cm
• If previously on anti-diabetic medication, should be off for at least 1 month

You may not qualify if…

• Active use of hypoglycemic agents (< 1 month)
• Renal failure, creatinine ≥ 1.5 mg/dL in men or ≥ 1.4 mg/dL in women
• Alanine aminotransferase levels exceed 135 IU/L or aspartate aminotransferase levels exceed 129 IU/L (3 x the upper limit of normal)
• Congestive Heart Failure (EF < 40 %)
• Active coronary artery disease
• Recent (less than 6 weeks) or planned imaging study requiring IV contrast
• Participation in structured exercise (> 2 hr per week)
• Recent change in dietary habits or weight
• Tobacco use
• Use of systemic glucocorticoids
• Anti-coagulant therapy (warfarin/heparin)
• Pregnancy or breastfeeding
• Alcohol consumption greater than 2 drinks/day
• Uncontrolled Hypothyroidism, abnormal thyroid stimulating hormone levels
• Metformin Allergy

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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