Neural Mechanisms of CBT Response in Hoarding Disorder
Completed · Not applicable
Conditions studied: Obsessive Compulsive Disorder
In brief
The purpose of this research is to measure changes in brain activity with functional magnetic resonance imaging (fMRI) before and after cognitive-behavioral therapy for compulsive hoarding. Cognitive-behavioral therapy aims to help people change the thoughts and behaviors that maintain symptoms of hoarding. The investigators intend to enroll approximately 80 people with hoarding disorder and 40 people with no psychiatric disorder, between the ages of 20 and 60, for this study. The investigators believe that after treatment there will be changes in the brain activity of individuals with compulsive hoarding.
Key facts
- Study ID
- NCT01956344
- Run by
- Hartford Hospital
- People needed
- 128
- Starts
- 2013-07-01
- Expected to finish
- 2019-06-01
- Last updated by the study team
- 2019-08-07
Who can join
Age: 20 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged 20-65
- Hoarding Disorder primary condition
- Score at least 4 on the CGI
- Free from all psychotropic medications for at least 4 weeks(5 weeks for fluoxetine)
- Participant is fluent in English
- Control over current living environment (i.e. not living in a nursing home or with relatives)
- Physically able to complete therapy assignments (i.e able to discard etc)
- Able to complete study measures
- If female: Using an approved method of contraception
You may not qualify if…
- More than 10 sessions of CBT for HD
- Actively suicidality, previous suicide attempt, current use of self harming behaviors or is at risk for harming others
- Current or past diagnosis of serious psychological disorder (psychotic disorder, bipolar disorder, substance use disorder or uncontrolled anorexia)
- Psychiatric hospitalization within the past 12 months
- History of anoxic or traumatic brain injury
- Evidence of cognitive dysfunction that would interfere in the ability to provide informed consent or engage in CBT
- Claustrophobia
- Pacemaker, aneurysm clip, or other metal in the body that would pose a risk during fMRI?
- If female: Pregnant or lactating
Where it is running
- Anxiety Disorders Center, Institute of Living — Hartford, Connecticut, United States
Full record on ClinicalTrials.gov
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