Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases

Withdrawn before enrolling

Conditions studied: Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson Disease

In brief

The etiology of many neurodegenerative diseases is unknown. A few studies have suggested the role of infection in the gastrointestinal tract in the etiology and pathogenesis of neurological diseases such as idiopathic Parkinson. For example, infection with Helicobacter pylori has been suggested to play a role in Parkinson disease. In addition, bacterial pathogens such as spirochetes and bacterial products such as cyanobacterial toxins have been speculated as the contributing factors in the development of amyotrophic lateral sclerosis (ALS). The effect of microbial composition of the gut in the pathogenesis of ALS is suspected. The difference in the bacterial profile of the gut has been documented in diseases such as inflammatory bowel disease and obesity. The goal of this IRB protocol is to create a human tissue bank and to obtain patients' demographic information for future investigation of the role of bacterial pathogens and the role of gut flora composition in the development of neurodegenerative diseases including but not limited to ALS, Parkinson's disease, and multiple sclerosis.

Key facts

Study ID

NCT01954875

Run by

Wake Forest University Health Sciences

People needed

0

Starts

2009-12-02

Expected to finish

2019-07-02

Last updated by the study team

2022-04-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• aged 18 years and older
• patients diagnosed with amyotrophic lateral sclerosis or other neurodegenerative disease, and healthy controls

You may not qualify if…

• Subjects with acute bacterial infection of the GI tract
• Subjects on treatments with antibiotics or probiotics within 28 days prior to sampling

Where it is running

• Carolinas Medical Center - Dept of Neurology — Charlotte, North Carolina, United States

Full record on ClinicalTrials.gov

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