Sildenafil Citrate Before Surgery in Improving Kidney Function in Patients With Kidney Cancer

Completed · Phase 1 · Has a placebo group

Conditions studied: Kidney Tumor

In brief

This randomized pilot clinical trial studies sildenafil citrate before surgery in improving kidney function in patients with kidney cancer. Sildenafil citrate may help protect the kidney from the side effects of surgery and improve kidney function after surgery.

Key facts

Study ID

NCT01950923

Run by

Wake Forest University Health Sciences

People needed

30

Starts

2013-09-01

Expected to finish

2016-03-01

Last updated by the study team

2018-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who are scheduled to undergo robotic partial nephrectomy for suspected renal malignancy
• Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

• Patients with a history of coronary artery disease (including history of myocardial infarction or cardiac stents) or a history of inducible ischemic changes on any prior cardiac stress testing
• History of adverse reactions to any phosphodiesterase (PDE) inhibitor (PDE type 5 inhibitor [PDE5i])
• Any patient currently taking a PDE5i will be asked to refrain from use for one week prior to their surgery; patients who have used a PDE5i within 72 hours of surgery will be excluded
• Pregnant women are excluded from this study
• Patients with only one kidney

Where it is running

• Comprehensive Cancer Center of Wake Forest University — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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