Early Levothyroxine Post Radioactive Iodine

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Graves' Disease

In brief

The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low thyroid hormone levels).

Key facts

Study ID

NCT01950260

Run by

Mayo Clinic

People needed

61

Starts

2013-09-01

Expected to finish

2017-04-01

Last updated by the study team

2019-10-29

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• all adult patients (ages 18-70 years) with Graves' Disease (GD) who will receive radioactive iodine (RAI) ablation of the thyroid gland for treatment of GD

You may not qualify if…

• clinically manifest Graves' ophthalmopathy (GO)
• recent (<1 yr.) history of arrhythmias or any history of ventricular arrhythmias
• preexistent cardiomyopathy
• malnutrition
• psychiatric history that could get worse if patient remains persistently hyperthyroid
• unlikely to return for the planned follow-up visits
• unlikely to comply with the blood drawing schedule
• unlikely to complete the hypothyroid-Health Related Quality of Life (HDQL) and Thyroid Specific (TSQ) questionnaires

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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