Impact of Feeding on Pro-Inflammatory Cytokine Response in Neonates Receiving a RBC Transfusion

Stopped early · Not applicable

Conditions studied: Transfusions

In brief

Prior to a non-urgent blood transfusion, subjects will be randomized to either stopping feeds or continuing feeds. The intervention group will be the placement of a subject in the NPO group. Subjects in the intervention group will have their feedings stopped for a total of 24 hours around the time of the PRBC transfusion. These infants will be given intravenous nutrition during the period of time that they will not be fed. During the transfusion, both groups of subjects will have serum cytokine levels obtained at 3 time intervals- 1) 4 hours pre-transfusion, 2) 2-4 hours post-transfusion, and 3) 20-24 hours post-transfusion.

Key facts

Study ID

NCT01949896

Run by

Christiana Care Health Services

People needed

12

Starts

2013-09-01

Expected to finish

2016-01-01

Last updated by the study team

2016-03-11

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Infants born < 31 weeks gestational age
• Between 3 and 7 days old at time of consent

You may not qualify if…

• Infants with multiple congenital anomalies
• Infant with suspected/confirmed genetic anomalies
• Infant with suspected/confirmed congenital immune deficiencies

Where it is running

• Christiana Care Health System — Newark, Delaware, United States

Full record on ClinicalTrials.gov

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